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Aurornis 40 minutes ago [-]
The surprising part is that neutering males after puberty showed the larger increase:
> However, mice that were neutered as adults gained the most. The procedure stretched their lives by about 33%, compared with 19% and 26% increases, respectively, for the animals fixed before or after puberty.
That trend goes opposite of what would be expected from a simple area under the curve model where presence of the testes correlated with reduced lifespan.
The link between male hormones and aging has always been interesting but I think there’s going to be a renewed interest as TRT clinics have become common and even men who aren’t hypogonadal can now be prescribed TRT after a short consult with a doctor from their local clinic who never turns anyone down.
Among the people I know who were more cavalier with TRT and keeping their testosterone levels at the top of the normal range for years, all of them have started talking about how it feels they’ve aged. Anecdotally, they look older than their age to me, but I didn’t realize how much testosterone was associated with accelerated aging until I looked at the research. I always thought the visual changes were a side effect of the associated hair growth changes, facial structure changes, and lifestyle factors that often come along with the people who use testosterone at levels above what’s needed to get toward the median of the range.
The numbers in this study preprint are close enough that I’d want to see more replication, but it would suggest that the relationship is more complicated than simply having androgens accelerate aging.
sandymcmurray 49 minutes ago [-]
It just seems longer.
m3kw9 32 seconds ago [-]
At a certain point, extending life span isn't everything.
world2vec 16 minutes ago [-]
This has always been known? Capons live longer than intact roosters. Wethers live longer than intact rams. Every farmer knows this.
sowbug 6 minutes ago [-]
Yes. The "surprising" part of the article is when the castration is performed.
SillyUsername 25 minutes ago [-]
I don't think anybody has the balls to try this tbh.
limaoscarjuliet 14 minutes ago [-]
Nice! :-)
throw8393098 40 minutes ago [-]
[flagged]
nico 2 minutes ago [-]
So is that why women on average live longer than men?
That would make a good case for castration after kids. But it needs to be sold really really well
moralestapia 1 minutes ago [-]
You vill lose ze ballz.
antonmks 22 minutes ago [-]
So we found a way to extend the human life. But, like usually, there is a catch.
swiftcoder 7 minutes ago [-]
Catch? You go through the prime of your life as male, and then prestige into Cat Girl.
OkayPhysicist 25 minutes ago [-]
IMO, all the evidence for castration increasing lifespan is pretty strong evidence that all the "I'm going to live 200 years" bluster by a certain contingent of techbros is merely that. I've yet to hear about any of them becoming eunuchs.
Earw0rm 20 minutes ago [-]
Disregard females, acquire seniority.
graemep 23 minutes ago [-]
I could imagine some of them doing it: they seem pretty desperate to live longer.
It reminds me of Larry Niven's Pak Protectors.
williamgators 44 minutes ago [-]
So does respecting the law but what fun is that?
HughParry 7 minutes ago [-]
paging bryan johnson
andrewclunn 39 minutes ago [-]
If mice studies were analogous to humans, we would have cured numerous things by now. I'm all for taking correlation as worthy of follow up research, but I aint chopping off my balls based on it.
yrjrjjrjjtjjr 30 minutes ago [-]
They note that castration is known to benefit longevity in a wide range of mammalian species. So I think there is a good chance there is something real here. Anyway the real prize is of course the castration mimetic drugs they hint at, that would give the benefits without having to actually remove the balls.
0x3444ac53 28 minutes ago [-]
There are better reasons to get your balls chopped off
jordanb 37 minutes ago [-]
New tech bro fad is gonna be bleak.
fullshark 4 minutes ago [-]
Need to see the studies on the productivity increases first before I consider it.
> However, mice that were neutered as adults gained the most. The procedure stretched their lives by about 33%, compared with 19% and 26% increases, respectively, for the animals fixed before or after puberty.
That trend goes opposite of what would be expected from a simple area under the curve model where presence of the testes correlated with reduced lifespan.
The link between male hormones and aging has always been interesting but I think there’s going to be a renewed interest as TRT clinics have become common and even men who aren’t hypogonadal can now be prescribed TRT after a short consult with a doctor from their local clinic who never turns anyone down.
Among the people I know who were more cavalier with TRT and keeping their testosterone levels at the top of the normal range for years, all of them have started talking about how it feels they’ve aged. Anecdotally, they look older than their age to me, but I didn’t realize how much testosterone was associated with accelerated aging until I looked at the research. I always thought the visual changes were a side effect of the associated hair growth changes, facial structure changes, and lifestyle factors that often come along with the people who use testosterone at levels above what’s needed to get toward the median of the range.
The numbers in this study preprint are close enough that I’d want to see more replication, but it would suggest that the relationship is more complicated than simply having androgens accelerate aging.
That would make a good case for castration after kids. But it needs to be sold really really well
It reminds me of Larry Niven's Pak Protectors.